Epigenetic regulation mediates adaptation to the environment by the genome lending plasticity that translates into the presenting phenotype, particularly under “mismatched” environmental ...

If epigenetics does have a significant impact on phenotype in mammals, it will present an interesting problem, as the rules governing this innate variation are likely to be completely different ...

Both DNA methylation and histone modifications contribute to the activated phenotype of systemic sclerosis fibroblasts. In vitro and in vivo experiments demonstrate that the use of epigenetic ...

Gene expression determines the phenotype of cells and tissues ... a structure that, via epigenetic programming, controls gene accessibility. Although all cells of our body share the same genome ...

Of particular interest is the silencing of tumor-suppressor genes by epigenetic alteration. Recent progress in understanding epigenetic modification and gene silencing has led to new opportunities ...

it returns totipotency for the first cells of a new individual and cell type-specific epigenetic profiles for adequate gene function will be formed again. This period appears to be particularly ...