研究发现，OPCs释放的HMGB1能够破坏血脑屏障（BBB），从而增加免疫细胞的浸润。与少突胶质细胞（OLs）相比，OPCs与EAE诱导小鼠的CD4?T细胞共培养时，可增强CD4?T细胞的迁移能力。在OPCs特异性HMGB1基因敲除（KO）小鼠中，血脑屏障（BBB）的通透性降低，免疫细胞浸润 ...

在CD4 + T细胞中，SOCS基因mRNA已被证明 ... 破坏了Th17细胞的分化和浸润，最终减弱了EAE的过程。 综上所述，研究人员重点强调了m 6 A修饰能够维持Th17 ...

Studies of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, have shown that B cells markedly influence the course of disease, but whether their effects are ...

So, T H cells that are polarized in the presence of IL-12p70 or IL-23 induce forms of EAE that are clinically identical but are mediated by distinctive effector populations and that respond ...

Milam's research interests are in the area cellular/molecular immunology and autoimmunity, with a focus on the link between affinity for self-antigen, cellular metabolism, and the primary and memory ...