This study uses multimodal imaging—including SHG, SIMS, and TEM—to reveal how fibroblasts interact with 3D collagen scaffolds ...

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

During the assembly of the fibronectin fibrils found in the ECM, the stretching of fibronectin might expose these potential intermolecular binding sites 9. Force, transduced from the cell’s ...

A new study has identified the protein ADAMTS5 as playing a crucial role in the spread of ovarian cancer cells, offering a ...

Human aging significantly contributes to cognitive decline and increased susceptibility to late-life neurodegenerative diseases (e.g.Alzheimer’ s disease, ...

Diabetes is a metabolic disorder caused by dysfunction in the pancreas, the organ responsible for regulating blood sugar levels. Within the pancreas, islet cells secrete insulin to lower blood sugar.

The researchers designed an efficient approach for fabricating engineered Pts-based nano-aircraft carriers with graded drug delivery and ECM degradation for precise cancer chemoimmunotherapy. Briefly, ...

"Penetrium introduces an innovative anticancer strategy, neutralizing ECM barriers that block effective drug and immune cell access to tumors. This preclinical outcome could be the world's first ...