This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...

Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, ...

Discover how next-generation kinase inhibitors are transforming clinical therapy byovercoming resistance and enhancing ...

British physician and microbiologist Alexander Fleming, discoverer of penicillin nearly 100 years ago, was the first to warn ...

Oncology, titled "Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention," a research team from Guangzhou ...

The increasing prevalence of nontuberculous mycobacteria (NTM) infections worldwide poses significant public health challenges, underscored by high fatality ...

The mechanisms suggested are based on findings from experimental laboratory studies of specific drug-uptake and drug-efflux transporters belonging to the superfamily of multidrug-resistance ...

The emergence of '-omics' technologies capable of yielding deep molecular profiles of cancer genomes has enabled the elucidation of somatic genetic alterations associated with resistance to ...

A new study unveils an innovative strategy to combat Pseudomonas aeruginosa, a major culprit behind food spoilage and ...

Drug-resistant infections occur when pathogens change in ways that render antimicrobial drugs ineffective. As a result, the pathogens survive and continue to spread. When infections are treatable with ...

This mechanism not only allows cancer cells to ... when this photoreactive compound was administered to mice with drug-resistant pancreatic cancer and subsequently exposed to infrared light ...