为探究调控蛋白和组蛋白尾巴存在时，调控 RNA 对 DNMT3A 的调控作用，研究人员开展了非编码 RNA 调控 DNMT3A 机制的研究。结果发现 Fos ecRNA 与 mRNA 相关，且调控 RNA 在多蛋白 - RNA 复合物中主导调节 DNMT3A 活性。该研究为理解表观遗传调控提供了新视角。 在生命的 ...

为解决颗粒暴露引发炎症疾病的机制问题，研究人员开展研究，揭示了AMPK-TFEB/TFE3-DNMT3A/DOT1L轴调控溶酶体酸化基因，JNK-AP-1 ...

英国伦敦弗朗西斯·克里克研究所的科研团队分析了从217名60至72岁、献血超过100次的德国男性血细胞中提取的遗传数据，还研究了212名年龄相仿、献血次数少于10次的男性样本，对比发现频繁献血者的血细胞更有可能携带一种名为DNMT3A的基因突变。 为理解这种 ...

Giving blood regularly may not just be saving the lives of other people, it could also be improving your own blood's health at a genetic level, according to a new study.

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...

Scientists compared blood from frequent, long-term donors to that of more seldom ones and saw some key genetic differences in cell types.

The results were surprising. Frequent donors had mutations in a gene called DNMT3A. This gene is known to mutate in people who develop leukemia. However, the specific changes seen in these blood ...

Specifically, both sample groups contained clones with changes in the DNMT3A gene, which is known to be mutated in people who can go on to develop blood cancers like leukemia. However ...

Frequent donors were found to carry mutations in the DNMT3A gene, which plays a key role in blood cell production. The scientists ran lab experiments using genetically modified human blood cells ...

“It suggests that, every blood donation, you’re going to have a burst of EPO in your system and this is going to favour the growth of cells with these DNMT3A mutations,” says Encab ...