So, we need repair enzymes that help us in maintaining DNA status, and OGG1 is taking care of one particular nuclear base that is guanine and OGG1, if it’s not removing it, we will have ...

New structural findings on APE1–DNA cocrystals provide insights into how this enzyme binds and cleaves ... dangerous steps in the base excision repair pathway. Figure 1: Schematic representation ...

Sequestration of an extrahelical nucleotide by DNA-bound ligase is reminiscent of the “base-flipping” mechanism of target site recognition and catalysis used by other DNA modification and repair ...

Homologous recombination plays essential roles in the repair ... DNA. This reaction is carried out by the RecA/Rad51 family of ATPases. In repair, the DSB is resected to produce ssDNA, which is then ...

The study helps partly explain why: the metabolic enzyme IMPDH2 relocates to the nucleus of TNBC cells to assist in DNA repair processes. "IMPDH2 acts like a mechanic in the cell's nucleus ...