γ-herpesvirus genomes encode an abundance of homologues of cellular factors, including cyclin and Bcl-2. These viral homologues differ from their cellular counterparts in that the viral proteins ...

In the 15 March issue of Nature, Bibb et al. 1 report the use of DNA array analysis of inducible transgenic mice to identify a cyclin-dependent kinase (Cdk5) that alters striatal dopamine (D1 ...

Cyclin B1 is relevant in mitosis, a type of cell division. The researchers observed how cyclin B1 docks onto substrates with its pocket and influences the behavior of the kinase as a result.

WILMINGTON, DE — NiKang Therapeutics® Inc. has achieved a pivotal step in the development of its first-in-class CDK2 degrader, NKT3964, by completing the dosing of the first patient cohort in a ...

Positive azenosertib clinical data demonstrated clinically meaningful results in patients with Cyclin E1+ platinum-resistant ovarian cancer ...