Joseph Priestley (1733–1804). This simplistic division of the roles of COX-1 and COX-2 drove the search for 'selective' COX-2 inhibitors and further fuelled the ranking of NSAIDs in terms of ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...

They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox enzymes, NSAIDs stop your body from ...