How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53 ... Wild-type p53 is often engaged in response to cellular damage, ...

However, the cell types involved in tumor calcification were particularly prevalent in ACP, while the cell cycle-associated genes were predominant in the PCP type. Further, the research team ...

Over 35 years ago, a group led by Dr. Lowy contributed to the early studies that identified RAS as a cancer-causing gene and helped explain how it promotes tumor growth. In this new study, the ...

There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, ...