CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

CRISPR/Cas9 is a gene editing tool that has revolutionized ... an intermediate "surveillance" structure serves as a gatekeeper to regulate the enzyme's DNA cutting activity. This step is key ...