≥65yrs: switching from highest dose of immediate-release carvedilol (25mg twice daily) to Coreg CR: initially Coreg CR 40mg; if tolerated for ≥2weeks, may increase to 80mg. Peripheral vascular ...

Carvedilol has the capacity to block both the β-1 and β-2 adrenergic receptors, as well as the α-1 receptors. There is evidence to indicate that full adrenergic blockade by carvedilol improves ...

To determine whether the β-blocker carvedilol reduces the incidence of atrial or ventricular arrhythmias in post-MI patients receiving ACE inhibitors. This was a substudy of the multinational ...

Maximum plasma concentrations of carvedilol occur 1-2 hours after oral administration. [9] Absolute bioavailability of carvedilol is approximately 23% due to extensive first-pass metabolism.