In the past 5–10 years there has been a growing trend for substituting conventional 5-fluorouracil with the oral prodrug of 5-fluorouracil, capecitabine ... This three-step pathway involves ...

The three metabolic enzymes responsible for the biotransformation of capecitabine to 5-FU show fairly specific expression in liver and tumor tissue. Following conversion to 5-FU, 60–90% of ...