whereas the inhibition of autophagy can sensitize cancer cells to chemotherapy to promote p53-induced apoptosis. Thus, manipulation of autophagy can determine cell-fate decisions in clinical settings.

Rett syndrome is a rare genetic disease affecting 1 in 10,000 newborn girls, characterized by sudden regression around 1 year ...

This can cause the cancer cell or parts of the cell—organelles—to shrink, expand or burst, rupture their membranes, or cause ...

Cancer cells are known for their remarkable adaptability, posing significant challenges in the development of effective treatments. One of their survival strategies is autophagy, a process in ...

Guan's lab has focused on how autophagy, or the cell's "recycling" function, affects cancer metastasis. "Autophagy can be ...

Mutations in serine-threonine kinase 11 (STK11) and liver kinase B1 (LKB1) are associated with disease progression in ...

Melanoma is one of the most aggressive skin cancers, with over 300,000 new cases reported worldwide each year. In Europe, the ...

Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning proteins and organelles. By reusing these basic molecules, the cell gains ...

Combination treatment with ibrilatazar and chemotherapy has demonstrated “promising efficacy and safety” in patients with advanced squamous non-small cell lung cancer (NSCLC), according to researchers ...

Gabrielė Varvuolytė, KTU Chemistry PhD candidate This can cause the cancer cell or parts of the cell - organelles - to shrink, expand or burst, rupture their membranes, or cause autophagy - a ...