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维生素D3通过抑制NLRP3炎症小体通路增强中性粒细胞型激素难治性哮喘 ...
针对激素难治性哮喘缺乏靶向治疗的难题,研究人员通过屋尘螨(HDM)和脂多糖(LPS)诱导的中性粒细胞型哮喘小鼠模型,揭示了活性维生素D 3 (calcitriol)通过泛素化调控NLRP3炎症小体通路,显著降低气道高反应性、IL-17释放及中性粒细胞浸润,并抑制GR-β表达 ...
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