为探究细胞色素 P450（CYP450）基因在金针菇（Flammulina filiformis）中的功能，研究人员开展了全基因组鉴定和转录组分析。结果鉴定出 59 个 CYP450 基因，发现其在不同发育阶段表达有差异，且部分基因与菌柄伸长有关。该研究为金针菇生长调控研究提供基础。

April 10, 2025) Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration ...

研究发现，葡萄柚中含有对白色香豆素类物质，它们能够显著抑制肠道和肝脏中的CYP3A4酶的活性。当这个酶的活性被抑制时，非奈利酮的代谢就会受阻，导致其在血液中的浓度升高。这样一来，患者可能面临着高钾血症和低血压的风险。危险的局面不止于此，葡萄柚与非奈利酮的相互作用还可能影响其他依赖CYP3A4代谢药物的效果。

Brian Tait, Chief Scientific Officer at Haplomic Technologies Pty Ltd, focuses here on CYP genes, haplotypes, and their ...

Of particular importance are cytochrome P450 enzymes, heme-containing mono-oxygenases which catalyze the final step in the incorporation of oxygen into organic molecules. They convert xenobiotics ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...