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1 天
非免疫靶向CXCR3通过破坏线粒体功能抑制胶质母细胞瘤生长的机制研究
本期推荐:香港大学研究团队针对胶质母细胞瘤(GBM)中CXCR3的非免疫功能展开研究,发现CXCR3-A亚型通过STAT3依赖途径调控线粒体功能促进肿瘤生长,使用选择性拮抗剂AMG487可显著抑制肿瘤进展。该研究首次揭示CXCR3在线粒体膜定位的新机制,为GBM治疗提供全新靶点。
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