HIV（人类免疫缺陷病毒）感染是全球重大健康难题。这篇研究聚焦 HIV-1 感染的巨噬细胞与 CD4 + T 细胞的相互作用，发现非感染性 CD4 + T 细胞可促进原代 HIV-1 在巨噬细胞中复制并形成 VCCs（病毒储存区室），为攻克 HIV 感染提供新方向，值得关注。

Flow cytometry was thrust into the spotlight by the AIDS epidemic in the 1980s as it provides a quick and accurate way to count CD4 + and CD8 + T cells in HIV-infected patients. Until recently ...

Target CD4+ T cells in unpurified whole blood samples were labelled with anti-CD4 antibody-coated beads and driven through the microfluidic chip by gravity-driven slug-flow where they were recorded ...

which allowed them to bind specifically to CD4+ T cells in the sample. The sample was then passed through the microfluidic chip, and the flow was recorded with an optical microscope and video camera.

More information: Desh Deepak Dixit et al, Artificial intelligence-enabled microfluidic cytometer using gravity-driven slug ...