Tovecimig, formerly known as CTX-009, is a bispecific antibody that blocks the Delta-like ligand 4 and vascular endothelial growth factor A signaling pathways.

Received positive feedback on New Drug Application submission via the 505(b)(2) pathway-Company leveraging existing human pharmacokinetic data ...

Bile duct inflammation and scarring, known as cholangiopathies, can disrupt bile flow, leading to liver damage and ...

As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al.

A new study from the Air Force Medical University, China shows that Sevoflurane (Sev) influences social functioning via the ...

Specifically, we would like to understand how these glycosyltransferases regulate the activity of the Notch signaling pathway in a dosage-sensitive and tissue-specific manner. We have reported a mouse ...

or metastatic HER2-positive (IHC 3+) biliary tract cancer whose disease status has been confirmed by an FDA-approved test. The agency has cleared Ziihera under its accelerated approval pathway ...

Researchers aimed to determine key pathways of interest ... immunologists don't generally spend a lot of time thinking about bile acids, and many of the associations between the specific bile ...