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攻克 ATM 突变前列腺癌:ATR 与 DNA-PKcs 双重靶向治疗新突破
研究人员针对 ATM 突变前列腺癌开展研究,发现 ATR 和 DNA-PKcs 双重抑制有疗效,Compound B 或可用于联合放疗。 在晚期去势抵抗性前列腺癌(CRPC)中,DNA 损伤反应(DDR)基因共济失调毛细血管扩张突变(ATM)发生突变的情况较为常见。尽管聚(ADP - 核糖)聚合酶 ...
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