APL is a distinct subtype of myeloid leukaemia that in almost 100% of cases is associated with chromosomal translocations involving the PML and retinoic acid receptor α (RARA) loci, leading to ...

How do ATRA and ATO affect leukaemia cells? APL is associated with a specific gene called PML-RARA (Promyelocytic Leukaemia Retinoic Acid Receptor Alpha). The PML-RARA gene is known to prevent the ...