Use of mycophenolate mofetil in ANCA-associated vasculitis has been evaluated only in small, noncontrolled cohort studies which were neither powered nor designed to demonstrate efficacy in the ...

导读抗中性粒细胞胞质抗体（ANCA）相关血管炎（AAV）是一组以血清中能检测到ANCA为最突出特点的系统性小血管炎，主要累及小血管（小动脉、微小动脉、微小静脉和毛细血管），但亦可有中等大小动脉受累，是临床最常见的一类系统性小血管炎。一般来说，AAV是 ...

Although immunosuppressive treatment of antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis results in a 10-year survival rate of 60–90%, a substantial number of patients suffer ...

导读美国风湿病学会（ACR）年会于2024年11月14~19日在美国华盛顿隆重召开。本次盛会聚集全球风湿免疫领域专家学者，共同探讨领域前沿。抗中性粒细胞胞质抗体（ANCA）相关血管炎（AAV）可累及多个器官系统，患者疾病负担严重[1]。近年来，围绕A ...

Avacopan treatment for vasculitis patients shows a significant risk of liver injury, especially in older and low-weight ...

ALEC-04 is under clinical development by Alentis Therapeutics and currently in Phase II for Nasopharyngeal Cancer.

RENAL-F02 is an ongoing Phase 2 study in Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV) with Rapidly Progressive Glomerulonephritis (RPGN) (NCT06047171), where 26 patients ...

In both clinical trials, lixudebart demonstrated a favorable safety profile, both as a monotherapy and in combination with standard of care (n=51 active patients across the two trials). These findings ...

Together with Churg–Strauss syndrome, microscopic polyarteritis (MPA) and renal limited vasculitis ... disorders is known collectively as the ANCA-associated vasculitides (AAV).

Cutaneous vasculitis (CV) is a term used for inflammation ... features of skin lesions include inflammation of the vessel wall associated with fibrinoid necrosis, extravasation of erythrocytes ...

YTS-109 is under clinical development by Bristar Immunotech Biotechnology and currently in Phase I for Polymyositis.

2025 surrounded by his family at the VA Medical Center in Iowa City from complications with Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)­Associated Vasculitis (AAV) plus Granulomatosis with ...