Patients with tumors that did not express thymidylate synthase responded to chemotherapy. Inhibition of thymidylate synthase is one of the main mechanisms of action of 5-FU and previous findings ...

Oncologists are accustomed to chemotherapy’s toxicity and tend to have a “no pain, no gain” attitude, he said. 5-FU has been in use since the 1950s. Yet “anybody who’s had a patient die ...