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3 天
MSK1 经 USP5 介导的 Snail 去泛素化稳定其蛋白,推动结直肠癌转移的 ...
结直肠癌(CRC)转移机制不明且死亡率高。研究人员开展 MSK1 在 CRC 转移中作用的研究,发现 MSK1 通过 USP5 介导 Snail 去泛素化,诱导上皮 - 间质转化(EMT)促进转移。该研究为 CRC 治疗提供潜在靶点和生物标志物。
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